Copa Sudamericana – Round of 16 (First Leg)

22 September 2015 
Deportes Tolima – Sportivo Luqueno
Referee: German Delfino (ARG, photo)
Assistant Referee 1: Hernan Maidana (ARG)
Assistant Referee 2: Ariel Scime (ARG)
Fourth Official: Wilson Lamouroux (COL)
Referee Observer: Demver Perdomo (COL)

23 September 2015
Emelec – Santa Fe
Referee: Ricardo Marques (BRA)
Assistant Referee 1: Rodrigo Correa (BRA)
Assistant Referee 2: Fabricio Vilarinho (BRA)
Fourth Official: Carlos Orbe (ECU)
Referee Observer: Juan Corozo (ECU)

River Plate – LDU Quito
Referee: Christian Ferreyra (URU)
Assistant Referee 1: Miguel Nievas (URU)
Assistant Referee 2: Gabriel Popovits (URU)
Fourth Official: Diego Ceballos (ARG)
Referee Observer: Miguel Scime (ARG)

Independiente – Olimpia
Referee: Heber Lopes (BRA)
Assistant Referee 1: Guilherme Camilo (BRA)
Assistant Referee 2: Cleriston Barreto (BRA)
Fourth Official: Pablo Diaz (ARG)
Referee Observer: Carlos Coradina (ARG)

Sport Recife – Huracan
Referee: Adrian Velez (COL)
Assistant Referee 1: Alexander Guzman (COL)
Assistant Referee 2: Wilmar Navarro (COL)
Fourth Official: Dewson Freitas (BRA)
Referee Observer: Milton Otaviano (BRA)

Atletico Paranaense – Brasília
Referee: Gery Vargas (BOL)
Assistant Referee 1: Javier Bustillos (BOL)
Assistant Referee 2: Edwin Paredes (BOL)
Fourth Official: Raphael Claus (BRA)
Referee Observer: Roberto Perassi (BRA)

24 September 2015
Libertad – Chapecoence
Referee: Roberto Tobar (CHI)
Assistant Referee 1: Christian Schiemann (CHI)
Assistant Referee 2: Claudio Rios (CHI)
Fourth Official: Carlos Amarilla (PAR)
Referee Observer: Ubaldo Aquino (PAR)

Lanus – Defensor Sporting
Referee: Jose Argote (VEN)
Assistant Referee 1: Luis Sanchez (VEN)
Assistant Referee 2: Tulio Moreno (VEN)
Fourth Official: Jorge Balino (ARG)
Referee Observer: Luis Pasturenzi (ARG)