19 April 2016Atlético Nacional – Huracán
Referee: Enrique Osses (CHI, photo)
Assistant Referee 1: José Retamal (CHI)
Assistant Referee 2: Claudio Rios (CHI)
Fourth Official: Eduardo Gamboa (CHI)
Referee Observer: Otálvaro Polanco (COL)
Peñarol – Sporting Cristal
Referee: Luiz De Oliveira (BRA)
Assistant Referee 1: Alessandro Rocha (BRA)
Assistant Referee 2: Fabricio Vilarinho (BRA)
Fourth Official: Leandro Vuaden (BRA)
Referee Observer: Juan Cardellino (URU)
San Lorenzo – Liga de Quito
Referee: Ulises Mereles (PAR)
Assistant Referee 1: Milciades Saldivar (PAR)
Assistant Referee 2: Darío Gaona (PAR)
Fourth Official: José Méndez (PAR)
Referee Observer: Carlos Coradina (ARG)
Gremio – Toluca
Referee: Gustavo Murillo (COL)
Assistant Referee 1: Wilmar Navarro (COL)
Assistant Referee 2: Alexander León (COL)
Fourth Official: Luis Sánchez (COL)
Referee Observer: José Mocellin (BRA)
20 April 2016
Boca Juniors – Deportivo Cali
Referee: Christian Ferreyra (URU)
Assistant Referee 1: Gabriel Popovits (URU)
Assistant Referee 2: Horacio Ferreiro (URU)
Fourth Official: Leondan Gonzalez (URU)
Referee Observer: Miguel Scime (ARG)
Bolívar – Racing
Referee: Fernando Guerrero (MEX)
Assistant Referee 1: Juan Rangel (MEX)
Assistant Referee 2: Miguel Hernández (MEX)
Fourth Official: Jorge Rojas (MEX)
Referee Observer: Pedro Saucedo (BOL)
Corinthians – Cobresal
Referee: Carlos Orbe (ECU)
Assistant Referee 1: Flavio Nall (ECU)
Assistant Referee 2: Edwin Bravo (ECU)
Fourth Official: Juan Albarracin (ECU)
Referee Observer: Nilson Moncao (BRA)
Cerro Porteño – Santa Fe
Referee: Heber Lopes (BRA)
Assistant Referee 1: Kleber Gil (BRA)
Assistant Referee 2: Bruno Boschilia (BRA)
Fourth Official: Anderson Daronco (BRA)
Referee Observer: Carlos Alarcon (PAR)
21 April 2016
River Plate – Trujillanos
Referee: Víctor Carrillo (PER)
Assistant Referee 1: Jorge Yupanqui (PER)
Assistant Referee 2: Víctor Raez (PER)
Fourth Official: Luis Garay (PER)
Referee Observer: Miguel Scime (ARG)
The Strongest – Sao Paulo
Referee: Roberto Tobar (CHI)
Assistant Referee 1: Francisco Mondria (CHI)
Assistant Referee 2: Raúl Orellana (CHI)
Fourth Official: Jorge Osorio (CHI)
Referee Observer: Iván Gamboa (BOL)
